Active Research Projects
Dendrites and axons show extraordinarily diverse forms and modes of patterning, with important implications for nervous system wiring and neuronal function. Our lab is interested in how neurons acquire their type-specific morphology and organization and how this organization underlies circuit function. To approach this problem, we use molecular, genetic, anatomical, and behavioral approaches to identify the mechanisms that sculpt somatosensory circuits during development.
How are dendritic territories established? How do cell-cell interactions determine where and how dendrites receive sensory or synaptic input? What are the cellular and molecular mechanisms of tiling and self-avoidance?
A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells