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Active Research Projects

Building neurons and circuits

Dendrites and axons show extraordinarily diverse forms and modes of patterning, with important implications for nervous system wiring and neuronal function. Our lab is interested in how neurons acquire their type-specific morphology and organization and how this organization underlies circuit function. To approach this problem, we use molecular, genetic, anatomical, and behavioral approaches to identify the mechanisms that sculpt somatosensory circuits during development.

Cell-cell interactions in dendrite development

How are dendritic territories established?  How do cell-cell interactions determine where and how dendrites receive sensory or synaptic input?   What are the cellular and molecular mechanisms of tiling and self-avoidance?

Recent Publication

A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells

O'Connor RM
Stone EF
Wayne CR
Marcinkevicius EV
Ulgherait M
Delventhal R
Pantalia MM
Hill VM
Zhou CG
McAllister S
Chen A
Ziegenfuss JS
Grueber WB
Canman JC
Shirasu-Hiza MM