Functional investigation of internal body sensing

How do internal sensory neurons detect body status and maintain homeostasis?

Sensing of internal body status is essential for proper functioning of many different organ systems.  In many cases, internal sensory neurons are important sensors and regulators of such physiological homeostasis.  We study the development and function of identified internal sensory neurons in Drosophila larvae.  We use an array of techniques to investigate sensory neuron function, including optogenetics, calcium imaging, activity manipulation and circuit reconstruction.  Our ultimate goal is to identify how internal sensory neurons sense and relay information about internal status and thus contribute to the maintenance of physiological systems throughout the body.