Grace joined the Grueber lab from Australia to pursue her interest in understanding the etiology of neurodegenerative conditions. She currently combines Drosophila larval and mouse models to identify how sensory nerve endings are maintained in health and diseases, particularly in the context of chemotherapy induced peripheral neuropathy (CIPN). She obtained her PhD in Professor Brian Key’s laboratory at the University of Queensland, Australia, studying the multi-faceted axon guidance molecule, RGMa. Upon completing her PhD, Grace joined Dr Sean Millard’s laboratory at the University of Queensland. Her research with Sean made important contributions to understanding how alternative splicing plays a role in neuronal wiring. Her work demonstrated that expression of two alternatively spliced isoforms encoded by a cell surface receptor gene Dscam2 is tightly regulated in the cells that are developing together, and this is critical for their correct neuronal wiring.
Grace is now an assistant professor at Ohio State University
SELECTED PUBLICATIONS
Shin, G. J.*, Pero, M. E., Hammond, L. A., Burgos, A., Kumar., A., Galindo S. E., Lucas T., Bartolini, F., Grueber, W. B. (2021) Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy. Proc Natl Acad Sci U S A doi: 10.1073/pnas.2006050118 *Corresponding author
Pero, M. E., Meregallim, C., Qu, X., Shin, G. J., Kumar., A., Shorey, M., Rolls, M., Tanji, K., Brannagan, T. H., Alberti, P., Fumagalli, G., Monza, L., Grueber, W. B., Cavaletti, G., Bartolini, F. (2021) Pathogenic Role of Delta 2 Tubulin in Bortezomib Induced Peripheral Neuropathy. Proc Natl Acad Sci U S A doi: 10.1073/pnas.2012685118
Odierna, G. L., Harris, L. E., Shin, G. J., Lavidis, N. A., Noakes, P. G., and Millard, S.S. (2020) Dscam2 suppresses synaptic strength via a phosphatidylinositol 3-kinase-dependent endosomal pathway. J Cell Biol 219 (6): e201909143.
Burgos, A., Honjo, K., Ohyama, T., Qian, C. S., Shin, G. J., Gohl, D. M., Silies, M., Tracey, W. D., Zlatic, M., Cardona, A., Grueber, W. B. (2018) Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila. eLife doi: 10.7554/eLife.26016
Tadros, W., Xu, S., Akin, O., Yi, C. H., Shin, G. J., Millard, S. S., Zipursky, S. L. (2016) Dscam proteins direct dendritic targeting through adhesion. Neuron 89(3):480-93
Lah (Shin), G. J.*, Li, J. S.*, and Millard, S. S. (2014) Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring. Neuron 83(6):1376-88. *Co-first authors